Patients also may be taking concomitant stimulants, similar to ephedra, which can confound data and the potential for opposed occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used within the therapy of reduced muscle mass and bone density as properly as anemia. The position testosterone might play within the growth of heart problems has more and more become the subject of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 natural and artificial derivatives of testosterone, could cause a large spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical apply just lately. Other common potential antagonistic results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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- Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in males with established coronary artery disease .
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- However, testosterone in physiologic doses may even be useful in patients with angina , have larger ischemic thresholds and improved quality of life .
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the proper coronary artery. Physicians and sufferers ought to be aware of the scientific penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
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However, testosterone in physiologic doses might even be beneficial in sufferers with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in men with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s threat profile as nicely as the testosterone dosing could additionally be problems with whether or not opposed occasions happen. Erythrocytosis has been reported as a possible effect of testosterone, which can be beneficial in patients with anemia.
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