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However, testosterone in physiologic doses could even be useful in sufferers with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in men with established coronary artery disease . Therefore, an interplay of endogenous factors of the patient’s danger profile in addition to the testosterone dosing could additionally be issues of whether or not opposed events occur. Erythrocytosis has been reported as a possible impact of testosterone, which may be useful in patients with anemia.
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- The position testosterone might play in the growth of heart problems has increasingly turn into the subject of present curiosity .
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and patients should pay attention to the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
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Patients also could also be taking concomitant stimulants, such as ephedra, which might confound information and the potential for opposed occasions. It is likely that the frequency of cardiac occasions is underreported in the medical literature. Moreover, testosterone has been used in the remedy of reduced muscle mass and bone density as nicely as anemia. The function testosterone might play within the development of cardiovascular disease has more and more turn out to be the subject of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embody greater than 30 natural and artificial derivatives of testosterone, might cause a large spectrum of clinical sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical follow just lately. Other frequent potential antagonistic results embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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